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Effect of salvia miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced digestive tract congestion

Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 317-322 doi: 10.1007/s11684-010-0035-4

Abstract: reperfusion periods 45 min following hepatic ischemia on the expression of cholecystokinin (CCK) and vasoactiveintestinal peptide (VIP) in the jejunum and the effect of salvia miltiorrhiza pretreatment were investigated

Keywords： hepatic ischemia-reperfusion     digestive tract congestion     cholecystokinin     vasoactive intestinal peptide    

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Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11705-014-1454-6

Abstract: Previous studies have found that three peptide inhibitors (i.e., KLVFF, VVIA, and LPFFD) can inhibitHowever, atomic details of binding modes and binding affinities between these peptide inhibitors andmolecular mechanics Poisson Boltzmann surface area (MM/PBSA) analysis, we examined the effect of three peptideMM/PBSA analysis further revealed that different peptide inhibitors have different modes of interactionprovides structure-based binding information for further modification and optimization of these three peptide

Keywords： Alzheimer’s disease     amyloid β-protein     peptide inhibitors     protein-protein interaction     molecular    

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ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

Frontiers of Medicine   Pages 972-992 doi: 10.1007/s11684-023-0990-1

Abstract: Moreover, ADT-OH reduced intestinal inflammation by suppressing the nuclear factor kappa-B pathway.In vivo and in vitro results showed that ADT-OH decreased intestinal permeability by increasingIn addition, ADT-OH restored intestinal microbiota dysbiosis characterized by the significantly increased

Keywords： inflammatory bowel disease     ADT-OH     intestinal permeability     gut microbiota    

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Cystine oligomers successfully attached to peptide cysteine-rich fibrils

Christian Bortolini,Mingdong Dong

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 99-102 doi: 10.1007/s11705-016-1554-6

Abstract: Amyloid peptides are renowned to be related to neurodegenerative diseases, however, a fruitful avenue is to employ them as high-performance nanomaterials. These materials benefit from the intrinsic outstanding mechanical robustness of the amyloid backbone made of -strands. In this work, we exploited amyloid-like fibrils as functional material to attach pristine L-cysteine aggregates (cystine oligomers) and gold nanoparticles, without the need of templating compounds. This work will open new avenues on functional materials design and their realisation.

Keywords： cysteine     peptide fibrils     gold nanoparticles     amyloids     oligomers     nanomaterials    

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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 368-373 doi: 10.1007/s11684-015-0403-1

Abstract:

Glucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimentalischemia/reperfusion (I/R) injury in pulmonary, intestinal, and myocardial tissue.

Keywords： ischemia/reperfusion     liver     glucagon-like peptide-2     alanine aminotransferase    

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Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 461-470 doi: 10.1007/s11684-019-0695-7

Abstract: The gut microbiota plays an important role in the development and progression of colorectal cancer (CRC). To learn more about the dysbiosis of carcinogenesis, we assessed alterations in gut microbiota in patients with CRC. A total of 23 subjects were enrolled in this study: 9 had CRC (CRC group) and 14 had normal colons (normal group). The microbiome of the mucosal–luminal interface of each subject was sampled and analyzed using 16S rRNA gene amplicon sequencing. We also used Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) to predict microbial functional profiles. The microbial composition of the mucosal lumen differed between the groups, and the presence of specific bacteria may serve as a potential biomarker for colorectal carcinogenesis. We identified a significant reduction in which is a butyrate-producing genera of bacteria, and a significant increase in in the gut microbiota of CRC patients. Different levels of gut microflora in healthy and CRC samples were identified. The observed abundance of bacterial species belonging to and may serve as a promising biomarker for the early detection of CRC.

Keywords： colorectal cancer (CRC)     gut microbiota     intestinal     Eubacterium     Devosia    

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The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 437-442 doi: 10.1007/s11684-009-0074-x

Abstract: Natriuretic peptide precursor A (NPPA) is synthesized, stored, and released by atrial myocytes.

Keywords： natriuretic peptide precursor A     coronary heart disease     gene polymorphism     allelic discrimination     polymorphism    

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Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 87-92 doi: 10.1007/s11684-007-0017-3

Abstract: The aim of this paper is to explore the effect of intestinal ischemia/reperfusion (I/R) injury on leptinAn intestinal I/R injury model of rats was made; the rats were grouped according to the time of afterLeptin and orexin-A respond to intestinal I/R injury in a time-dependent manner, with leptin responding

Keywords： significant difference     intestinal I/R     transcriptase-polymerase     metabolic     central secretory    

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Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 9-19 doi: 10.1007/s11705-013-1306-9

Abstract: innovative silica-based, mucoadhesive oral insulin formulation with encapsulated-insulin/cell penetrating peptideIt was also confirmed that low molecular weight protamine (LMWP) behaves like a CPP peptide, with a celldevelopment of a generic platform for oral delivery of many other bioactive compounds, especially for peptide

Keywords： insulin     cell penetrating peptide     mucoadhesive composites     oral delivery    

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Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation

Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,

Engineering doi: 10.1016/j.eng.2023.01.015

Abstract: In particular, a designed antifreeze peptide named AVD exhibits ideal ice recrystallization inhibitionanalysis and molecular dynamics (MD) simulations indicated that the Thr6 and Asn8 residues of the AVD peptideFurthermore, to demonstrate the cryoprotection potential of AVD, the peptide was successfully employedThis work opens up a new avenue for designing antifreeze materials and provides peptide-based functional

Keywords： Antifreeze peptides     Evolution analysis     Ice recrystallization inhibition     Molecular dynamics simulation     Cryopreservation     Synthetic biology    

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Multi-Peptide Adsorption on Uncharged Solid Surfaces: A Coarse-Grained Simulation Study Research

Ruosang Qiu, Jie Xiao, Xiao Dong Chen

Engineering 2020, Volume 6, Issue 2,   Pages 185-194 doi: 10.1016/j.eng.2018.12.012

Abstract: It was observed that around half (46.6%) of the 12-Ala peptide chains could form aggregates. 30.0% ofThe change in the solid-liquid interface due to peptide deposition has a potential influence on the furtheradsorption of single peptide chains and aggregates in the bulk water.Overall, the findings from this work help to reveal the mechanism of multi-peptide adsorption, and consequentially

Keywords： Peptide chains     Aggregates     Adsorption     Coarse-grained simulation    

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Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating

Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5,   Pages 889-901 doi: 10.1007/s11705-020-1919-8

Abstract: Herein, the multitargeting REDV-G-TAT-G-NLS peptide was conjugated to amphiphilic cationic copolymerECs-targeting ability, cell-penetrating ability and nuclear targeting capacity of REDV-G-TAT-G-NLS peptide

Keywords： gene carriers     multitargeting function     ECs     transfection efficiency    

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Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting

Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 1,   Pages 220-220 doi: 10.1007/s11705-020-1995-9

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Structural shifts in the intestinal microbiota of rats treated with cyclosporine A after orthotropic

Junjun Jia, Xinyao Tian, Jianwen Jiang, Zhigang Ren, Haifeng Lu, Ning He, Haiyang Xie, Lin Zhou, Shusen Zheng

Frontiers of Medicine 2019, Volume 13, Issue 4,   Pages 451-460 doi: 10.1007/s11684-018-0675-3

Abstract: Understanding the effect of immunosuppressive agents on intestinal microbiota is important to reduceinvestigated the relationship between the commonly used immunosuppressive agent cyclosporine A (CSA) and the intestinalThe intestinal microbiota was assayed by denaturing gradient gel electrophoresis profiles and by using

Keywords： microbial community     liver transplantation     immunosuppressive agents     cyclosporine A    

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Ca-Alginate-Based Janus Capsules with a Pumping Effect for Intestinal-Targeted Controlled Release Article

Shuang Wen, XiaoJie Ju, Wenying Liu, Yuqiong Liu, Xingqun Pu, Zhuang Liu, Wei Wang, Rui Xie, Yousef Faraj, Liangyin Chu

Engineering 2023, Volume 24, Issue 5,   Pages 114-125 doi: 10.1016/j.eng.2022.05.021

Abstract:

A novel intestinal-targeted θ-shaped capsule with a pumping effect for the controlled releaseshell offers improved protection for the encapsulated drug in the stomach environment and excellent intestinal-targetedprovide a potential and novel model for developing responsive pumping controlled-release systems and intestinal-targeted

Keywords： Capsules     Ca-alginate     Intestinal-targeted delivery     Pumping effects     Controlled release    

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Title Author Date Type Operation

Effect of salvia miltiorrhiza pretreatment on the CCK and VIP expression in hepatic ischemia-reperfusion-induced digestive tract congestion

Zhi-Yong ZHANG, Xiao-Ping CHEN, Qi-Ping LU

Journal Article

Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Journal Article

ADT-OH improves intestinal barrier function and remodels the gut microbiota in DSS-induced colitis

Journal Article

Cystine oligomers successfully attached to peptide cysteine-rich fibrils

Christian Bortolini,Mingdong Dong

Journal Article

Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Journal Article

Altered intestinal microbiota associated with colorectal cancer

Hong Zhang, Ying Chang, Qingqing Zheng, Rong Zhang, Cheng Hu, Weiping Jia

Journal Article

The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Journal Article

Effect of intestinal ischemia/reperfusion injury on leptin and orexin-A levels

LIN Ji, YAN Guangtao, HAO Xiuhua, ZHANG Kai, GAO Xiaoning, LIAO Jie

Journal Article

Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Journal Article

Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation

Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,

Journal Article

Multi-Peptide Adsorption on Uncharged Solid Surfaces: A Coarse-Grained Simulation Study

Ruosang Qiu, Jie Xiao, Xiao Dong Chen

Journal Article

Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating

Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng

Journal Article

Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting

Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng

Journal Article

Structural shifts in the intestinal microbiota of rats treated with cyclosporine A after orthotropic

Junjun Jia, Xinyao Tian, Jianwen Jiang, Zhigang Ren, Haifeng Lu, Ning He, Haiyang Xie, Lin Zhou, Shusen Zheng

Journal Article

Ca-Alginate-Based Janus Capsules with a Pumping Effect for Intestinal-Targeted Controlled Release

Shuang Wen, XiaoJie Ju, Wenying Liu, Yuqiong Liu, Xingqun Pu, Zhuang Liu, Wei Wang, Rui Xie, Yousef Faraj, Liangyin Chu

Journal Article